Sunday, September 23, 2012

In vivo genome editing using a high-efficiency TALEN system

Improvements in artificial transcription activator-like effector nucleases (TALENs) provide a powerful new approach for targeted zebrafish genome editing and functional genomic applications1–5. Using the Goldy TALEN modified scaffold and zebrafish delivery system, it was shown that this enhanced TALEN toolkit has a high efficiency in inducing locus-specific DNA breaks in somatic and germline tissues. 
Science
Nature (2013) Sept 23 
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