Sunday, January 20, 2013

Grid cells require excitatory drive from the hippocampus

To determine how hippocampal backprojections influence spatially periodic firing in grid cells, the author recorded neural activity in the medial entorhinal cortex (MEC) of rats after temporary inactivation of the hippocampus. They report two major changes in entorhinal grid cells. First, hippocampal inactivation gradually and selectively extinguished the grid pattern. Second, the same grid cells that lost their grid fields acquired substantial tuning to the direction of the rat's head. This transition in firing properties was contingent on a drop in the average firing rate of the grid cells and could be replicated by the removal of an external excitatory drive in an attractor network model in which grid structure emerges by velocity-dependent translation of activity across a network with inhibitory connections. These results point to excitatory drive from the hippocampus, and possibly other regions, as one prerequisite for the formation and translocation of grid patterns in the MEC.

Tora Bonnevie, et al.
Nature Neuroscience (2013) doi:10.1038/nn.3311, Published online 20 January 2013


12 comments:

  1. Great post! I am actually getting ready to across this information, is very helpful my friend. Also great blog here with all of the valuable information you have. Keep up the good work you are doing here.
    bubblegum casting

    ReplyDelete
  2. I would love to stop by. But, I think it might have to wait until this summer. I did not know that Serlkay had ever expanded its size. I must say that a succesful family owned business in this day and age is a very refreshing sight! As well as this is a very refreshing site!
    best mattress for lower back pain

    ReplyDelete
  3. Great post full of useful tips! My site is fairly new and I am also having a hard time getting my readers to leave comments. Analytics shows they are coming to the site but I have a feeling “nobody wants to be first”. is memory foam safe

    ReplyDelete
  4. This transition in firing properties was contingent on a drop in the average firing rate of the grid cells and could be replicated by the removal of an external excitatory drive in an attractor network model in which grid structure emerges by velocity-dependent translation of activity across a network with inhibitory connections. gel memory foam mattress review

    ReplyDelete
  5. These results point to excitatory drive from the hippocampus, and possibly other regions, as one prerequisite for the formation and translocation of grid patterns in the MEC. Consumer Reports rates best mattress

    ReplyDelete
  6. These results point to excitatory drive from the hippocampus, and possibly other regions, as one prerequisite for the formation and translocation of grid patterns in the MEC. gel foam mattress reviews

    ReplyDelete
  7. I was watching Dr Oz show in which dr showed some cells from garcinia cambogia extract that how these cell fight for weight loss.

    ReplyDelete
  8. There are many products to cure hemorrhoids you can also buy venapro to cure you hemorrhoids.

    ReplyDelete
  9. Great website. Lots of helpful info here. I am sending it to a few friends ans additionally sharing in delicious. And obviously, thank you to your sweat!

    ویزای تحصیلی کانادا

    ReplyDelete
  10. سلام بهترین متخصص ارتودنسی در تهران کدوم دکتره؟
    پرسش سختی رو مطرح کردین. ملاک های زیادی برای تشخیص بهترین متخصص ارتودنسی وجود دارن. بیشتر متخصصان ارتودنسی در ایران توانایی های لازم برای درمان ناهنجاری های فک و ارتودنسی رو دارا هستن و کما اینکه ایران یکی از مقصد های توریسم سلامت محسوب میشه. ولی بهتر هست که شما مسائلی مانند سوابق پزشک، موقعیت مکانی نزدیکتر، و بهترین شیوه های درمان ارتودنسی را در انتخاب پزشک خود لحاظ بکنید.

    ReplyDelete
  11. سلام دوستان بهترین آموزشی که در تبدیل وی سی اف به اکسل وجود دارد به همراه آموزش
    تبدیل excel به vcf
    قرار داده ای.

    ReplyDelete
  12. Pretty nice post. I just stumbled upon your weblog and wanted to say that I have really enjoyed browsing your blog posts. http://www.gamekyo.com/blog95644.html

    ReplyDelete