Friday, December 21, 2012
How do environments talk to genes?
In Nature Neuroscience January 2013 issue, Moshe Szyf explains the environmental interaction onto genes. A report elucidates the widely recognized, but poorly understood, concept of gene-environment interaction, finding a molecular mechanism in the case of post-traumatic stress disorder: demethylation of a glucocorticoid response element in the stress response regulator FKBP5 that depends on both the risk allele and childhood trauma.
Moshe Szyf Nature Neuroscience 16, 2–4 (2013) doi:10.1038/nn.3286
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