Sunday, July 1, 2012

Evolution of Synapse Complexity and Diversity

Proteomic studies of the composition of mammalian synapses have revealed a high degree of complexity. The postsynaptic and presynaptic terminals are molecular systems with highly organized protein networks producing emergent physiological and behavioral properties. The major classes of synapse proteins and their respective functions in intercellular communication and adaptive responses evolved in prokaryotes and eukaryotes prior to the origins of neurons in metazoa. In eukaryotes, the organization of individual proteins into multiprotein complexes comprising scaffold proteins, receptors, and signaling enzymes formed the precursor to the core adaptive machinery of the metazoan postsynaptic terminal. Multiplicative increases in the complexity of this protosynapse machinery secondary to genome duplications drove synaptic, neuronal, and behavioral novelty in vertebrates. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior.

Richard D. Emes1 and Seth G.N. Grant2
Annual Review of Neuroscience
Vol. 35: 111-131 (Volume publication date July 2012)
DOI: 10.1146/annurev-neuro-062111-150433

23 comments:

  1. First You got a great blog .I will be interested in more similar topics. i see you got really very useful topics , i will be always checking your blog thanks.
    bubblegum casting

    ReplyDelete
  2. Once I thought about things like: why such information is for free here? Because when you write a book then at least on selling a book you get a percentage. Thank you and good luck on informing people more about it!
    best mattress for lower back pain

    ReplyDelete
  3. Great, This specific net webpage is seriously thrilling and enjoyment to learn. I’m an enormous fan from the subjects mentioned. is memory foam safe

    ReplyDelete
  4. in vertebrates. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. gel foam mattress reviews

    ReplyDelete
  5. vertebrates. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organizationConsumer Reports reveals top mattress picks

    ReplyDelete
  6. and behavioral novelty in vertebrates. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. gel foam mattress reviews

    ReplyDelete
  7. secondary to genome duplications drove synaptic, neuronal, and behavioral novelty in vertebrates. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. Best Mattresses rated by Consumer Reports

    ReplyDelete
  8. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. Top Rated Mattresses 2014

    ReplyDelete
  9. mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. memory foam off gassing

    ReplyDelete
  10. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. adjustable bed mattress

    ReplyDelete
  11. Once I thought about things like: why such information is for free here? Because when you write a book then at least on selling a book you get a percentage. Thank you and good luck on informing people more about it!
    plant-based memory foam mattress

    ReplyDelete
  12. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. Best Mattresses rated by Consumer Reports

    ReplyDelete
  13. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. best gel memory foam mattress

    ReplyDelete
  14. mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. memory foam off-gassing

    ReplyDelete
  15. vertebrates. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. best bed for back pain

    ReplyDelete
  16. in vertebrates. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of s is memory foam safe

    ReplyDelete
  17. Great post full of useful tips! My site is fairly new and I am also having a hard time getting my readers to leave comments. Analytics shows they are coming to the site but I have a feeling “nobody wants to be first”.
    mattress shopping

    ReplyDelete
  18. It was great to see the old printshop and everyone who works there again. I am excited to see a printing business still operating and growing, great job guys
    memory foam vocs

    ReplyDelete
  19. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. piala dunia 2014

    ReplyDelete
  20. Wow! What an eye opener this post has been for me. Very much appreciated, bookmarked, I can’t wait for more!
    sleep hygiene

    ReplyDelete
  21. What a good blog you have here. Please update it more often. This topics is my interest. Thank you. . .
    buying a new mattress

    ReplyDelete
  22. Natural selection has constrained diversification in mammalian postsynaptic mechanisms and the repertoire of adaptive and innate behaviors. The evolution and organization of synapse proteomes underlie the origins and complexity of nervous systems and behavior. reports best mattress

    ReplyDelete